Scale-up approach for the preparation of magnetic ferrite nanocubes and other shapes with benchmark performance for magnetic hyperthermia applications

Helena Gavilán, Giusy M. R. Rizzo, Niccolò Silvestri, Binh T. Mai, Teresa Pellegrino

Published: 2023-01-26 DOI: 10.1038/s41596-022-00779-3

magnetic ferrite

nanocubes

solvothermal synthesis

hyperthermia applications

shape control

AI 解读

Supplementary information

Supplementary Information

Supplementary experimental section, water transfer protocols (Boxes 1–4), characterizations, Figs. 1–23, Tables 1–3 and References.

Reporting Summary

Efficient and safe single-cell cloning of human pluripotent stem cells using the CEPT cocktail

Profiling native pulmonary basement membrane stiffness using atomic force microscopy

Genetic circuit design automation with Cello 2.0

Synthesis of siRNA nanoparticles to silence plaque-destabilizing gene in atherosclerotic lesional macrophages

Scalable dual-omics profiling with single-nucleus chromatin accessibility and mRNA expression sequencing 2 (SNARE-seq2)

A practical guide to scanning light-field microscopy with digital adaptive optics

Effective high-throughput isolation of fully human antibodies targeting infectious pathogens

Improved sampling and DNA extraction procedures for microbiome analysis in food-processing environments

MOF-derived nanoporous carbons with diverse tunable nanoarchitectures

Tutorial: a statistical genetics guide to identifying HLA alleles driving complex disease

查看全部

Sections

Figures

References

Supplementary information

Ferrari, M. Cancer nanotechnology: opportunities and challenges. Nat. Rev. Cancer 5, 161–171 (2005).
Simeonidis, K. et al. In-situ particles reorientation during magnetic hyperthermia application: shape matters twice. Sci. Rep. 6, 38382 (2016).
Ulbrich, K. et al. Targeted drug delivery with polymers and magnetic nanoparticles: covalent and noncovalent approaches, release control, and clinical studies. Chem. Rev. 116, 5338–5431 (2016).
Mai, B. T., Fernandes, S., Balakrishnan, P. B. & Pellegrino, T. Nanosystems based on magnetic nanoparticles and thermo-or pH-responsive polymers: an update and future perspectives. Acc. Chem. Res. 51, 999–1013 (2018).
Farzin, A., Etesami, S. A., Quint, J., Memic, A. & Tamayol, A. Magnetic nanoparticles in cancer therapy and diagnosis. Adv. Healthc. Mater. 9, 1901058 (2020).
Irvine, D. J. & Dane, E. L. Enhancing cancer immunotherapy with nanomedicine. Nat. Rev. Immunol. 20, 321–334 (2020).
Mahmoudi, K., Bouras, A., Bozec, D., Ivkov, R. & Hadjipanayis, C. Magnetic hyperthermia therapy for the treatment of glioblastoma: a review of the therapy’s history, efficacy and application in humans. Int. J. Hyperth. 34, 1316–1328 (2018).
Helena Gavilán, S. K. A. et al. Magnetic nanoparticles and clusters for magnetic hyperthermia: optimizing their heat performance and developing combinatorial therapies to tackle cancer. Chem. Soc. Rev. http://doi.org/10.1039/D1CS00427A (2021).
Tatarchuk, T., Bououdina, M., Judith Vijaya, J. & John Kennedy, L. Spinel ferrite nanoparticles: synthesis, crystal structure, properties, and perspective applications. In Int. Conf. on Nanotechnol. Nanomater. Vol. 195, 305–325 (Springer, 2016).
Kefeni, K. K., Msagati, T. A., Nkambule, T. T. & Mamba, B. B. Spinel ferrite nanoparticles and nanocomposites for biomedical applications and their toxicity. Mater. Sci. Eng. C. 107, 110314 (2020).
Frey, N. A., Peng, S., Cheng, K. & Sun, S. Magnetic nanoparticles: synthesis, functionalization, and applications in bioimaging and magnetic energy storage. Chem. Soc. Rev. 38, 2532–2542 (2009).
Roca, A. et al. Progress in the preparation of magnetic nanoparticles for applications in biomedicine. J. Phys. Appl. Phys. 42, 224002 (2009).
Martinez-Boubeta, C. et al. Learning from nature to improve the heat generation of iron-oxide nanoparticles for magnetic hyperthermia applications. Sci. Rep. 3, 1652 (2013).
Gandia, D. et al. Unlocking the potential of magnetotactic bacteria as magnetic hyperthermia agents. Small 15, 1902626 (2019).
Alphandery, E., Faure, S., Seksek, O., Guyot, F. & Chebbi, I. Chains of magnetosomes extracted from AMB-1 magnetotactic bacteria for application in alternative magnetic field cancer therapy. ACS Nano 5, 6279–6296 (2011).
Kim, D. et al. Synthesis of uniform ferrimagnetic magnetite nanocubes. J. Am. Chem. Soc. 131, 454–455 (2009).
Cullity, B. D. & Graham, C. D. Introduction to Magnetic Materials (John Wiley & Sons, 2011).
Fock, J. et al. On the ‘centre of gravity’method for measuring the composition of magnetite/maghemite mixtures, or the stoichiometry of magnetite-maghemite solid solutions, via 57Fe Mössbauer spectroscopy. J. Phys. D. Appl. Phys. 50, 265005 (2017).
Salazar-Alvarez, G. et al. Cubic versus spherical magnetic nanoparticles: the role of surface anisotropy. J. Am. Chem. Soc. 130, 13234–13239 (2008).
Noh, S.-h et al. Nanoscale magnetism control via surface and exchange anisotropy for optimized ferrimagnetic hysteresis. Nano Lett. 12, 3716–3721 (2012).
Espinosa, A. et al. Duality of iron oxide nanoparticles in cancer therapy: amplification of heating efficiency by magnetic hyperthermia and photothermal bimodal treatment. ACS Nano 10, 2436–2446 (2016).
Guardia, P. et al. Water-soluble iron oxide nanocubes with high values of specific absorption rate for cancer cell hyperthermia treatment. ACS Nano 6, 3080–3091 (2012).
Guardia, P. et al. One pot synthesis of monodisperse water soluble iron oxide nanocrystals with high values of the specific absorption rate. J. Mater. Chem. B 2, 4426–4434 (2014).
Yang, L. et al. Composition tunable manganese ferrite nanoparticles for optimized T 2 contrast ability. Chem. Mater. 29, 3038–3047 (2017).
Lee, J.-H. et al. Exchange-coupled magnetic nanoparticles for efficient heat induction. Nat. Nanotechnol. 6, 418–422 (2011).
Sathya, A. et al. CoxFe3–xO4 nanocubes for theranostic applications: effect of cobalt content and particle size. Chem. Mater. 28, 1769–1780 (2016).
Silvestri, N. et al. Di-and tri-component spinel ferrite nanocubes: synthesis and their comparative characterization for theranostic applications. Nanoscale 13, 13665–13680 (2021).
Lartigue, L. et al. Biodegradation of iron oxide nanocubes: high-resolution in situ monitoring. Acs Nano 7, 3939–3952 (2013).
Kolosnjaj-Tabi, J. et al. Heat-generating iron oxide nanocubes: subtle “destructurators” of the tumoral microenvironment. ACS Nano 8, 4268–4283 (2014).
Mai, B. T. et al. Thermoresponsive iron oxide nanocubes for an effective clinical translation of magnetic hyperthermia and heat-mediated chemotherapy. ACS Appl. Mater. Interfaces 11, 5727–5739 (2019).
Avugadda, S. K. et al. Esterase-cleavable 2D assemblies of magnetic iron oxide nanocubes: exploiting enzymatic polymer disassembling to improve magnetic hyperthermia heat losses. Chem. Mater. 31, 5450–5463 (2019).
Zyuzin, M. V. et al. Confining iron oxide nanocubes inside submicrometric cavities as a key strategy to preserve magnetic heat losses in an intracellular environment. ACS Appl. Mater. Interfaces 11, 41957–41971 (2019).
Roca, A. G. et al. Design strategies for shape-controlled magnetic iron oxide nanoparticles. Adv. Drug Deliv. Rev. 138, 68–104 (2019).
Kovalenko, M. V. et al. Fatty acid salts as stabilizers in size-and shape-controlled nanocrystal synthesis: the case of inverse spinel iron oxide. J. Am. Chem. Soc. 129, 6352–6353 (2007).
Guardia, P., Pérez, N., Labarta, A. & Batlle, X. Controlled synthesis of iron oxide nanoparticles over a wide size range. Langmuir 26, 5843–5847 (2010).
Gao, G. et al. Shape-controlled synthesis and magnetic properties of monodisperse Fe3O4 nanocubes. Cryst. Growth Des. 10, 2888–2894 (2010).
Xu, Z., Shen, C., Tian, Y., Shi, X. & Gao, H.-J. Organic phase synthesis of monodisperse iron oxide nanocrystals using iron chloride as precursor. Nanoscale 2, 1027–1032 (2010).
Wang, Z. L. Transmission electron microscopy of shape-controlled nanocrystals and their assemblies. J. Phys. Chem. B 104, 1153–1175 (2000).
Khurshid, H. et al. Synthesis and magnetic properties of core/shell FeO/Fe3O4 nano-octopods. J. Appl. Phys. 113, 17B508 (2013).
Niculaes, D. et al. Asymmetric assembling of iron oxide nanocubes for improving magnetic hyperthermia performance. ACS Nano 11, 12121–12133 (2017).
Muro-Cruces, J. et al. Precise size control of the growth of Fe3O4 nanocubes over a wide size range using a rationally designed one-pot synthesis. ACS Nano 13, 7716–7728 (2019).
Gilbert, K. & Gajewski, J. Coal liquefaction model studies: free radical chain decomposition of diphenylpropane, dibenzyl ether, and phenethyl phenyl ether via. beta.-scission reactions. J. Org. Chem. 47, 4899–4902 (1982).
Qiao, L. et al. Standardizing size-and shape-controlled synthesis of monodisperse magnetite (Fe3O4) nanocrystals by identifying and exploiting effects of organic impurities. ACS Nano 11, 6370–6381 (2017).
Johannsen, M. et al. Clinical hyperthermia of prostate cancer using magnetic nanoparticles: presentation of a new interstitial technique. Int. J. Hyperth. 21, 637–647 (2005).
Johannsen, M. et al. Thermotherapy of prostate cancer using magnetic nanoparticles: feasibility, imaging, and three-dimensional temperature distribution. Eur. Urol. 52, 1653–1662 (2007).
Jordan, A. et al. Presentation of a new magnetic field therapy system for the treatment of human solid tumors with magnetic fluid hyperthermia. J. Magn. Magn. Mater. 225, 118–126 (2001).
Maier-Hauff, K. et al. Efficacy and safety of intratumoral thermotherapy using magnetic iron-oxide nanoparticles combined with external beam radiotherapy on patients with recurrent glioblastoma multiforme. J. Neurooncol. 103, 317–324 (2011).
Thiesen, B. & Jordan, A. Clinical applications of magnetic nanoparticles for hyperthermia. Int. J. Hyperth. 24, 467–474 (2008).
Hühn, J. et al. Selected standard protocols for the synthesis, phase transfer, and characterization of inorganic colloidal nanoparticles. Chem. Mater. 29, 399–461 (2017).
Fortin, J.-P. et al. Size-sorted anionic iron oxide nanomagnets as colloidal mediators for magnetic hyperthermia. J. Am. Chem. Soc. 129, 2628–2635 (2007).
Shin, Y. J. et al. Centrifugal shape sorting and optical response of polyhedral gold nanoparticles. Adv. Mater. 25, 4023–4027 (2013).
Park, J. et al. Ultra-large-scale syntheses of monodisperse nanocrystals. Nat. Mater. 3, 891–895 (2004).
Gonzales-Weimuller, M., Zeisberger, M. & Krishnan, K. M. Size-dependant heating rates of iron oxide nanoparticles for magnetic fluid hyperthermia. J. Magn. Magn. Mater. 321, 1947–1950 (2009).
Castellanos-Rubio, I. et al. Outstanding heat loss via nano-octahedra above 20 nm in size: from wustite-rich nanoparticles to magnetite single-crystals. Nanoscale 11, 16635–16649 (2019).
Lak, A. et al. Fe2+ deficiencies, FeO subdomains, and structural defects favor magnetic hyperthermia performance of iron oxide nanocubes into intracellular environment. Nano Lett. 18, 6856–6866 (2018).
Krishnan, S., Bhardwaj, S., Liu, S., Xing, R. & Chavali, M. Handbook of Greener Synthesis of Nanomaterials and Compounds (Elsevier Amsterdam, The Netherlands:, 2021).
Tunison, B. R. Industrial alcohol. J. Franklin Inst. 190, 373–420 (1920).
Richardson, J. J. & Caruso, F. Nanomedicine Toward 2040 (ACS Publications, 2020).
Das, R. et al. Tunable high aspect ratio iron oxide nanorods for enhanced hyperthermia. J. Phys. Chem. C. 120, 10086–10093 (2016).
Das, R. et al. Boosted hyperthermia therapy by combined AC magnetic and photothermal exposures in Ag/Fe3O4 nanoflowers. ACS Appl. Mater. Interfaces 8, 25162–25169 (2016).
Sun, H. et al. Solvothermal synthesis of tunable electroactive magnetite nanorods by controlling the side reaction. J. Phys. Chem. C. 116, 5476–5481 (2012).
Nemati, Z. et al. Enhanced magnetic hyperthermia in iron oxide nano-octopods: size and anisotropy effects. J. Phys. Chem. C. 120, 8370–8379 (2016).
Byrappa, K. & Yoshimura, M. Handbook of Hydrothermal Technology (William Andrew, 2012).
Quarta, A., Curcio, A., Kakwere, H. & Pellegrino, T. J. N. Polymer coated inorganic nanoparticles: tailoring the nanocrystal surface for designing nanoprobes with biological implications. Nanoscale 4, 3319–3334 (2012).
Connord, V., Mehdaoui, B., Tan, R., Carrey, J. & Respaud, M. An air-cooled Litz wire coil for measuring the high frequency hysteresis loops of magnetic samples—a useful setup for magnetic hyperthermia applications. Rev. Sci. Instrum. 85, 093904 (2014).
Gneveckow, U. et al. Description and characterization of the novel hyperthermia‐and thermoablation‐system for clinical magnetic fluid hyperthermia. J. Med. Phys. 31, 1444–1451 (2004).
Del Sol-Fernández, S. et al. Flower-like Mn-doped magnetic nanoparticles functionalized with α v β3-integrin-ligand to efficiently induce intracellular heat after alternating magnetic field exposition, triggering glioma cell death. ACS Appl. Mater. Interfaces 11, 26648–26663 (2019).
Hergt, R. & Dutz, S. Magnetic particle hyperthermia—biophysical limitations of a visionary tumour therapy. J. Magn. Magn. Mater. 311, 187–192 (2007).
Gutiérrez, L. et al. Aggregation effects on the magnetic properties of iron oxide colloids. Nanotechnology 30, 112001 (2019).
Périgo, E. A. et al. Fundamentals and advances in magnetic hyperthermia. Appl. Phys. Rev. 2, 041302 (2015).
Pellegrino, T. et al. Hydrophobic nanocrystals coated with an amphiphilic polymer shell: a general route to water soluble nanocrystals. Nano Lett. 4, 703–707 (2004).
Leal, M. P. et al. Long-circulating PEGylated manganese ferrite nanoparticles for MRI-based molecular imaging. Nanoscale 7, 2050–2059 (2015).
Salas, G. et al. Modulation of magnetic heating via dipolar magnetic interactions in monodisperse and crystalline iron oxide nanoparticles. J. Phys. Chem. C. 118, 19985–19994 (2014).
Salas, G. et al. Controlled synthesis of uniform magnetite nanocrystals with high-quality properties for biomedical applications. J. Mater. Chem. 22, 21065–21075 (2012).
Persano, S. et al. Elucidating the innate immunological effects of mild magnetic hyperthermia on U87 human glioblastoma cells: an in vitro study. Pharmaceutics 13, 1668 (2021).
Bordet, A. et al. Magnetically induced continuous CO2 hydrogenation using composite iron carbide nanoparticles of exceptionally high heating power. Angew. Chem. Int. Ed. 55, 15894–15898 (2016).
Martínez-Prieto, L. M. et al. Ultrastable magnetic nanoparticles encapsulated in carbon for magnetically induced catalysis. ACS Appl. Nano Mater. 3, 7076–7087 (2020).
Tucek, J., Kemp, K. C., Kim, K. S. & Zboril, R. Iron-oxide-supported nanocarbon in lithium-ion batteries, medical, catalytic, and environmental applications. ACS Nano 8, 7571–7612 (2014).
Talapin, D. V., Lee, J.-S., Kovalenko, M. V. & Shevchenko, E. V. Prospects of colloidal nanocrystals for electronic and optoelectronic applications. Chem. Rev. 110, 389–458 (2010).
Pellegrino, T. et al. Method for the gram-scale preparation of cubic ferrite nanocrystals for biomedical applications. International patent WO 2020/222133 (2020): http://patentscope.wipo.int/search/en/detail.jsf?docId=WO2020222133
Pellegrino, T. et al. Method for the gram-scale preparation of ferrite nanoparticles for magnetic hyperthermia applications. International patent WO 2022/090316 (2022): http://patentscope.wipo.int/search/en/detail.jsf?docId=WO2022090316

Scale-up approach for the preparation of magnetic ferrite nanocubes and other shapes with benchmark performance for magnetic hyperthermia applications

Supplementary information

Supplementary Information

Reporting Summary

推荐阅读