Preparation of near-infrared AIEgen-active fluorescent probes for mapping amyloid-β plaques in brain tissues and living mice

Chenxu Yan, Jianfeng Dai, Yongkang Yao, Wei Fu, He Tian, Wei-Hong Zhu, Zhiqian Guo

Published: 2023-01-24 DOI: 10.1038/s41596-022-00789-1

fluorescent probe

blood–brain barrier

AIEgen

amyloid-β plaque

Alzheimer’s disease

AI 解读

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Fibrillar aggregates of the amyloid-β protein (Aβ) are the main component of the senile plaques found in brains of patients with Alzheimer’s disease (AD). Development of probes allowing the noninvasive and high-fidelity mapping of Aβ plaques invi
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ACKNOWLEDGMENTS

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Preparation of near-infrared AIEgen-active fluorescent probes for mapping amyloid-β plaques in brain tissues and living mice

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