Establishment of human induced trophoblast stem cells via reprogramming of fibroblasts

Xiaodong Liu, Jia Ping Tan, Jose M. Polo

Published: 2022-10-13 DOI: 10.1038/s41596-022-00742-2

induced trophoblast stem cells

fibroblast reprogramming

Yamanaka factors

patient-specific iTS cells

trophoblast biology

AI 解读

Generation of mouse–human chimeric embryos

Genome-wide quantification of transcription factor binding at single-DNA-molecule resolution using methyl-transferase footprinting

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Single-cell RNA sequencing (scRNA-seq)（单细胞RNA测序）

Data integration（数据集成）

Heterogeneity（异质性）

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During early mammalian embryonic development, trophoblast cells play an essential role in establishing cell–nobreakcell interactions at the maternal–nobreakfetal interface to ensure a successful pregnancy. In a recent study, we showed that
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ACKNOWLEDGMENTS

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Establishment of human induced trophoblast stem cells via reprogramming of fibroblasts

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